Naproxen can cause kidney problems, especially when used for extended periods of time or in high doses. The use of naproxen has been associated with an increased risk of acute kidney injury, particularly in people who have pre-existing kidney problems or risk factors for kidney disease, such as dehydration, heart failure, and advanced age.

People with a history of kidney disease or a history of kidney problems should use naproxen with caution and talk to their doctor before using it. It is also important to drink plenty of water and stay hydrated while taking naproxen to help reduce the risk of kidney problems.

If you experience symptoms of kidney problems while taking naproxen, such as swelling in the feet or legs, dark urine, or changes in the amount or frequency of urination, seek medical attention immediately.

In conclusion, naproxen can cause kidney problems in some people, especially when used for extended periods of time or in high doses. It is important to talk to your doctor before using naproxen to make sure it is safe and appropriate for you, and to carefully follow the instructions on the label.