Over-the-counter (OTC) naproxen sodium is a widely used nonsteroidal anti-inflammatory drug (NSAID) for the treatment of mild to moderate pain. Clinical studies have supported the use of OTC naproxen sodium as a nonopioid option for pain relief.

One study conducted in 2012 compared the efficacy and safety of OTC naproxen sodium to that of acetaminophen in patients with knee osteoarthritis. The results showed that naproxen sodium was more effective in reducing pain and improving physical function compared to acetaminophen.

Another study published in 2013 assessed the efficacy and safety of OTC naproxen sodium for the treatment of primary dysmenorrhea (painful menstrual periods). The study found that naproxen sodium was effective in reducing pain and improving quality of life in these patients.

A systematic review and meta-analysis published in 2016 evaluated the effectiveness and safety of OTC NSAIDs, including naproxen sodium, for the treatment of acute pain conditions, such as headache, toothache, and menstrual cramps. The results showed that OTC naproxen sodium was effective in reducing pain and had a similar safety profile to other OTC NSAIDs.

In conclusion, the clinical evidence supports the use of OTC naproxen sodium as a nonopioid option for pain relief. However, it’s important to remember that all medications, including OTC naproxen sodium, have potential risks and side effects, and it’s always important to talk to a healthcare professional before starting any new medication.